APOL1 Genetic Variants Are Associated With Increased Risk of Coronary Atherosclerotic Plaque Rupture in the Black Population

Arterioscler Thromb Vasc Biol. 2021 Jul;41(7):2201-2214. doi: 10.1161/ATVBAHA.120.315788. Epub 2021 May 27.

Abstract

[Figure: see text].

Keywords: apolipoprotein; cardiovascular disease; coronary artery disease; kidney; plaque, atherosclerotic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Apolipoprotein L1 / genetics*
  • Autopsy
  • Black or African American / genetics*
  • Cause of Death
  • Coronary Artery Disease / ethnology
  • Coronary Artery Disease / genetics*
  • Coronary Artery Disease / mortality
  • Coronary Artery Disease / pathology
  • Coronary Thrombosis / ethnology
  • Coronary Thrombosis / genetics*
  • Coronary Thrombosis / mortality
  • Coronary Thrombosis / pathology
  • Death, Sudden, Cardiac / ethnology
  • Death, Sudden, Cardiac / pathology
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genetic Variation*
  • Haplotypes
  • Humans
  • Male
  • Maryland / epidemiology
  • Middle Aged
  • Necrosis
  • Phenotype
  • Plaque, Atherosclerotic*
  • Registries
  • Risk Assessment
  • Risk Factors
  • Rupture, Spontaneous

Substances

  • APOL1 protein, human
  • Apolipoprotein L1