Convalescent plasma as a treatment modality for Coronavirus Disease 2019 in Indonesia: A case reports

Achmad Thabrani; Wahid Syamsul Hadi; Jarir At Thobari; Zakiah Novianti; Kurniyanto; Indah Juliana; Agus Suharto; Atik Nuriyah Danaswari; Ika Septiani; Sholahuddin Rhatomy

doi:10.1016/j.amsu.2021.102444

Convalescent plasma as a treatment modality for Coronavirus Disease 2019 in Indonesia: A case reports

Ann Med Surg (Lond). 2021 Jun:66:102444. doi: 10.1016/j.amsu.2021.102444. Epub 2021 May 31.

Authors

Achmad Thabrani^{1

2}, Wahid Syamsul Hadi^{1

2}, Jarir At Thobari³, Zakiah Novianti^{1

2}, Kurniyanto^{1

2}, Indah Juliana^{1

2}, Agus Suharto^{1

2}, Atik Nuriyah Danaswari^{1

2}, Ika Septiani^{1

2}, Sholahuddin Rhatomy^{1

2}

Affiliations

¹ Dr. Soeradji Tirtonegoro General Hospital, Klaten, Indonesia.
² Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
³ Department of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Special Region of Yogyakarta, Indonesia.

Abstract

Introduction and importance: Coronavirus Disease 2019 (COVID-19) has become a pandemic since the beginning of 2020. COVID-19 is also spreading very rapidly in Indonesia and so far, no definitive therapy has been found.

Case presentation: We report two cases of confirmed COVID-19 with moderate pneumonia, who received 400 ml of convalescent plasma and showed improvements in clinical, laboratory and radiological examinations.

Clinical discussion: Passive immunotherapy is generally more effective when given early. Plasma transfusion is more beneficial when given before clinical conditions become severe. Some studies have shown that therapy with convalescent plasma can contribute to a longer survival and a lower length of stay.

Conclusion: Convalescent plasma can be used as an adjunctive therapy option for patients with moderate COVID-19.

Keywords: Adjunctive therapy treatment; COVID-19; Case report; Convalescent plasma.

Publication types

Case Reports