Molecular omics resources should require sex annotation: a call for action

Kamila M Bond; Margaret M McCarthy; Joshua B Rubin; Kristin R Swanson

doi:10.1038/s41592-021-01168-6

Molecular omics resources should require sex annotation: a call for action

Nat Methods. 2021 Jun;18(6):585-588. doi: 10.1038/s41592-021-01168-6.

Authors

Kamila M Bond^{1

2}, Margaret M McCarthy^{3

4}, Joshua B Rubin^{5

6}, Kristin R Swanson⁷

Affiliations

¹ Mathematical Neuro-Oncology Lab, Department of Neurological Surgery, Mayo Clinic, Phoenix, AZ, USA.
² Mayo Clinic School of Medicine, Rochester, MN, USA.
³ Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA.
⁴ Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA.
⁵ Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA.
⁶ Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
⁷ Mathematical Neuro-Oncology Lab, Department of Neurological Surgery, Mayo Clinic, Phoenix, AZ, USA. swanson.kristin@mayo.edu.

Abstract

The most commonly-used omics databases are a compilation of results from primarily male-only and sex-agnostic studies. The pervasive use of these databases critically hinders progress towards fully accounting for the biology of sex differences.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Computational Biology / methods
Database Management Systems*
Female
Genomics*
Humans
Male
Metabolomics*
Proteomics*
Sex Factors*

Abstract

Publication types

MeSH terms

Grants and funding