Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study

Tu'uhevaha J Kaitu'u-Lino; Stephen Tong; Susan P Walker; Teresa M MacDonald; Ping Cannon; Tuong-Vi Nguyen; Suresh Anand Sadananthan; Mya-Thway Tint; Yi Ying Ong; Loy See Ling; Peter D Gluckman; Yap-Seng Chong; Keith M Godfrey; Shiao-Yng Chan; Kok Hian Tan; Yung Seng Lee; Navin Michael; Johan G Eriksson; Mary E Wlodek

doi:10.1016/j.placenta.2021.05.007

Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study

Placenta. 2021 Jul:110:24-28. doi: 10.1016/j.placenta.2021.05.007. Epub 2021 Jun 1.

Authors

Tu'uhevaha J Kaitu'u-Lino¹, Stephen Tong², Susan P Walker³, Teresa M MacDonald³, Ping Cannon⁴, Tuong-Vi Nguyen⁴, Suresh Anand Sadananthan⁵, Mya-Thway Tint⁶, Yi Ying Ong⁷, Loy See Ling⁸, Peter D Gluckman⁹, Yap-Seng Chong⁶, Keith M Godfrey¹⁰, Shiao-Yng Chan⁶, Kok Hian Tan¹¹, Yung Seng Lee¹², Navin Michael⁵, Johan G Eriksson¹³, Mary E Wlodek¹⁴

Affiliations

¹ Translational Obstetrics Group, Mercy Hospital for Women, 163 Studley Road, Heidelberg, 3084, Victoria, Australia; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia. Electronic address: t.klino@unimelb.edu.au.
² Translational Obstetrics Group, Mercy Hospital for Women, 163 Studley Road, Heidelberg, 3084, Victoria, Australia; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia.
³ The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia.
⁴ Translational Obstetrics Group, Mercy Hospital for Women, 163 Studley Road, Heidelberg, 3084, Victoria, Australia; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia.
⁵ Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.
⁶ Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
⁷ Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
⁸ Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, 229899; Duke-NUS Medical School, Singapore, 169857.
⁹ Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Liggins Institute, University of Auckland, Auckland, New Zealand.
¹⁰ MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, UK.
¹¹ Department of Maternal FetaL Medicine KK Women's and Children's Hospital Singapore, Singapore.
¹² Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
¹³ Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Folkhälsan Research Center, Helsinki, Finland.
¹⁴ The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia; Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

PMID: 34102451
DOI: 10.1016/j.placenta.2021.05.007

Abstract

Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Circulating SPINT1 concentrations were significantly lower among 141 pregnant women destined to deliver small-for-gestational age infants (birthweight <10th centile), compared to 772 controls (p < 0.01) at as early as 26 weeks' gestation. There were no correlations between infant body composition and circulating SPINT1 concentrations at 26 weeks. This provides validation that low maternal SPINT1 concentration is associated with poor fetal growth.

Keywords: Biomarker; Fetal growth restriction; SGA; SPINT1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Birth Weight / physiology
Case-Control Studies
Cohort Studies
Down-Regulation
Female
Fetal Growth Retardation / blood*
Fetal Growth Retardation / epidemiology
Gestational Age
Humans
Infant, Newborn
Infant, Small for Gestational Age
Outcome Assessment, Health Care
Placental Insufficiency / blood*
Placental Insufficiency / epidemiology
Pregnancy
Pregnancy Outcome / epidemiology
Pregnancy Trimester, Second / blood
Proteinase Inhibitory Proteins, Secretory / analysis
Proteinase Inhibitory Proteins, Secretory / blood*
Singapore / epidemiology
Stillbirth / epidemiology

Substances

Proteinase Inhibitory Proteins, Secretory
SPINT1 protein, human

Abstract

Publication types

MeSH terms

Substances

Grants and funding