Dual-energy CT (DECT) is an emerging imaging technique and has become increasingly available in Danish hospitals in recent years. DECT utilizes data acquired from high and low kV photons. This allows for the separation of materials based on their atomic buildup, which can be visualised and quantified during post-processing. DECT entails a broad range of clinical applications across multiple organ systems and can support diagnostic decision-making as described in this review. DECT is not yet widely utilised mainly due to limited knowledge combined with a new workflow for the radiologist.