Knowledge bases and software support for variant interpretation in precision oncology

Florian Borchert; Andreas Mock; Aurelie Tomczak; Jonas Hügel; Samer Alkarkoukly; Alexander Knurr; Anna-Lena Volckmar; Albrecht Stenzinger; Peter Schirmacher; Jürgen Debus; Dirk Jäger; Thomas Longerich; Stefan Fröhling; Roland Eils; Nina Bougatf; Ulrich Sax; Matthieu-P Schapranow

doi:10.1093/bib/bbab246

Knowledge bases and software support for variant interpretation in precision oncology

Brief Bioinform. 2021 Nov 5;22(6):bbab246. doi: 10.1093/bib/bbab246.

Authors

Florian Borchert¹, Andreas Mock^{2

3}, Aurelie Tomczak^{4

5}, Jonas Hügel^{6

7}, Samer Alkarkoukly⁸, Alexander Knurr⁹, Anna-Lena Volckmar⁴, Albrecht Stenzinger⁴, Peter Schirmacher^{4

5}, Jürgen Debus^{10

11

12

13

14}, Dirk Jäger^{3

15}, Thomas Longerich^{4

5}, Stefan Fröhling^{2

16}, Roland Eils^{17

18}, Nina Bougatf^{10

11

12

13

14}, Ulrich Sax^{6

7}, Matthieu-P Schapranow¹

Affiliations

¹ Digital Health Center, Hasso Plattner Institute (HPI), University of Potsdam, Prof.-Dr.-Helmert-Str. 2-3, 14482 Potsdam, Germany.
² Department of Translational Medical Oncology (TMO), National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.
³ Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.
⁴ Institute of Pathology Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.
⁵ Liver Cancer Center Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.
⁶ Department of Medical Informatics, University Medical Center Göttingen, Von-Siebold-Str. 3, 37099 Göttingen, Germany.
⁷ Campus Institute Data Science, Göttingen, Germany.
⁸ CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Joseph-Stelzmann-Straße 26, 50931 Cologne.
⁹ Division of Medical Informatics for Translational Oncology, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
¹⁰ Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
¹¹ National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.
¹² Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
¹³ Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 450, 69120 Heidelberg, Germany.
¹⁴ Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
¹⁵ Clinical Coorporation Unit Applied Tumor-Immunity, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
¹⁶ German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
¹⁷ Health Data Science Unit, Heidelberg University Hospital, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany.
¹⁸ Center for Digital Health, Berlin Institute of Health and Charité Universitötsmedizin Berlin, Kapelle-Ufer 2, 10117 Berlin, Germany.

No abstract available

Publication types

Published Erratum