A Case of Sepsis Due to Carbapenem-Resistant Klebsiella pneumoniae in an Extremely Low-Birth Weight Infant Treated with Trimethoprim-Sulfamethoxazole

Bowen Weng; Xiaoyue Zhang; Wenchao Hong; Chongbing Yan; Xiaohui Gong; Cheng Cai

doi:10.2147/IDR.S312183

A Case of Sepsis Due to Carbapenem-Resistant Klebsiella pneumoniae in an Extremely Low-Birth Weight Infant Treated with Trimethoprim-Sulfamethoxazole

Infect Drug Resist. 2021 Jun 22:14:2321-2325. doi: 10.2147/IDR.S312183. eCollection 2021.

Authors

Bowen Weng¹, Xiaoyue Zhang¹, Wenchao Hong¹, Chongbing Yan¹, Xiaohui Gong¹, Cheng Cai¹

Affiliation

¹ Department of Neonatology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, People's Republic of China.

Abstract

In recent years, there have been an increasing number of infections due to multidrug-resistant organisms in the neonatal intensive care unit. Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a challenge in clinical anti-infection treatment. Herein, we report the case of CRKP sepsis in an extremely low-birth weight infant (ELBWI) who did not respond to meropenem and vancomycin, but was treated successfully after a 10-day antibiotic course with trimethoprim-sulfamethoxazole (TMP-SMZ). Recent research on CRKP-associated sepsis and the application of TMP-SMZ therapy in children and neonates were reviewed to offer a reference for clinical practice.

Keywords: Klebsiella pneumoniae; carbapenem-resistance; extremely low birth weight infant; sepsis; trimethoprim–sulfamethoxazole.

Publication types

Case Reports