Results of treatment of 4018 patients with acute pancreatitis (including 267 cases of destructive pancreatitis) for the last decade has shown that no promising results were obtained in spite of the introduction of new surgical and nonsurgical methods into clinical practice. High percent of lethal outcomes (70%) among patients with acute pancreatitis who have acute gastric ulcers, and the absence of clear understanding of the mechanisms require further investigation of the problem.