Glucose Derivative Induced Vasculopathy in Children on Chronic Peritoneal Dialysis

Circ Res. 2021 Aug 20;129(5):e102-e118. doi: 10.1161/CIRCRESAHA.121.319310. Epub 2021 Jul 8.

¹ Center for Pediatric and Adolescent Medicine (M.B., C.Z., B.S., I.D., E.L., I.M., F.S., S.G.Z., C.P.S.), University of Heidelberg, Heidelberg, Germany.
² Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria (R.H., M.U., A.W., K.K.).
³ Kirchhoff Institute for Physics (D.R., G.H.), University of Heidelberg, Heidelberg, Germany.
⁴ ELKH-SE, Pediatrics and Nephrology Research Group, Budapest, Hungary (E.L.).
⁵ 1st Department of Pediatrics, Semmelweis University, Budapest, Hungary (E.L., P.S.).
⁶ Institute of Pathology (C.E.), University of Heidelberg, Heidelberg, Germany.
⁷ Division of Pediatric Surgery, Department of General, Visceral and Transplantation Surgery (P.R.), University of Heidelberg, Heidelberg, Germany.
⁸ Division of Nephrology, Heidelberg University Hospital, Heidelberg, Germany (A.U.).
⁹ Children's Mercy Kansas City, Kansas City, MO (B.A.W.).
¹⁰ Department of Physiology, Faculty of Medicine, University of Thessaly, Larissa, Greece (S.G.Z.).

Abstract

[Figure: see text].

Trial registration: ClinicalTrials.gov NCT01893710.

Keywords: apoptosis; chronic renal insufficiency; cytoskeleton; endothelium; peritoneal dialysis; proteome; vascular diseases.