Coronavirus Disease 2019 (COVID-19) Outbreak Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) P.1 Lineage in a Long-Term Care Home After Implementation of a Vaccination Program-Ontario, Canada, April-May 2021

Chantal Williams; Dana Al-Bargash; Celeste Macalintal; Rebecca Stuart; Anu Seth; Julienne Latham; Leah Gitterman; Stephanie Fedsin; Marion Godoy; Robert Kozak; Jennifer L Guthrie; Heidi Wood; Allison McGeer; Susy Hota; Elizabeth Rea

doi:10.1093/cid/ciab617

Coronavirus Disease 2019 (COVID-19) Outbreak Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) P.1 Lineage in a Long-Term Care Home After Implementation of a Vaccination Program-Ontario, Canada, April-May 2021

Clin Infect Dis. 2022 Mar 23;74(6):1085-1088. doi: 10.1093/cid/ciab617.

Authors

Chantal Williams¹, Dana Al-Bargash², Celeste Macalintal³, Rebecca Stuart², Anu Seth², Julienne Latham³, Leah Gitterman¹, Stephanie Fedsin¹, Marion Godoy³, Robert Kozak^{4

5}, Jennifer L Guthrie⁶, Heidi Wood⁷, Allison McGeer^{5

8

9}, Susy Hota^{1

10}, Elizabeth Rea^{2

9}

Affiliations

¹ Infection Prevention and Control Department, University Health Network, Toronto, Ontario, Canada.
² Toronto Public Health, Toronto, Ontario, Canada.
³ Responsive Management, Toronto, Ontario, Canada.
⁴ Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
⁵ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
⁶ Public Health Ontario Laboratory, Toronto, Ontario, Canada.
⁷ National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
⁸ Department of Microbiology, Sinai Health System, Toronto, Ontario, Canada.
⁹ Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
¹⁰ Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

PMID: 34240103
DOI: 10.1093/cid/ciab617

Abstract

In a P.1 coronavirus disease 2019 (COVID-19) outbreak in a long-term care home, vaccine effectiveness against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was 52.5% (95% confidence interval: 26.9%-69.1%) in residents and 66.2% (2.3%-88.3%) in staff. Vaccine effectiveness against severe illness was 78.6% (47.9%-91.2%) in residents. Two of 19 vaccinated resident case patients died. Outbreak management required both vaccination and infection control measures.

Keywords: COVID-19; SARS-CoV-2; long term care; outbreak; vaccination.

MeSH terms

COVID-19* / prevention & control
Disease Outbreaks / prevention & control
Humans
Long-Term Care
Ontario / epidemiology
SARS-CoV-2*
Vaccination

Grants and funding

Public Health Agency of Canada