Hashimoto's Thyroiditis-Associated Acute Renal Failure and Pitfalls of eGFR Interpretation in Thyroid Diseases

Frank-Peter Tillmann; Ana Harth; Achim Jörres

doi:10.12890/2021_002645

Hashimoto's Thyroiditis-Associated Acute Renal Failure and Pitfalls of eGFR Interpretation in Thyroid Diseases

Eur J Case Rep Intern Med. 2021 Jun 22;8(7):002645. doi: 10.12890/2021_002645. eCollection 2021.

Authors

Frank-Peter Tillmann^{1

2}, Ana Harth¹, Achim Jörres¹

Affiliations

¹ Department of Medicine I, University Witten/Herdecke, Medical Center Cologne-Merheim, Germany.
² Nephrological Centres Münsterland, Ibbenbüren, Germany.

Abstract

The authors describe a patient with severe hypothyroidism due to Hashimoto's thyroiditis and describe the pitfalls of estimated glomerular filtration rate interpretation in such cases.

Learning points: Manifest hypothyroidism can lead to a functional reduction in glomerular filtration rates (GFRs).Restoration of a normal thyroid stimulating hormone (TSH) will also restore kidney function.Cystatin C-based GFR formulas will overestimate renal filtration rates in cases of hypothyroidism and underestimate GFRs in cases of hyperthyroidism.

Keywords: AKIN; Hashimoto; cystatin C; eGFR; thyroiditis.