Allergy and the Heart: Eosinophilic Myocarditis With Biventricular Thrombi

Cullen E Buchanan; Ekta Kakkar; Stephen C Dreskin; Larry A Allen; Daniel W Groves; Natasha L Altman

doi:10.1016/j.jaccas.2020.07.046

Allergy and the Heart: Eosinophilic Myocarditis With Biventricular Thrombi

JACC Case Rep. 2020 Oct 7;2(12):1942-1946. doi: 10.1016/j.jaccas.2020.07.046. eCollection 2020 Oct.

Authors

Cullen E Buchanan¹, Ekta Kakkar², Stephen C Dreskin², Larry A Allen³, Daniel W Groves³, Natasha L Altman³

Affiliations

¹ Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
² Department of Medicine, Division of Allergy and Immunology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
³ Department of Medicine-Cardiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Abstract

A 40-year-old woman with history of atopy and peripheral eosinophilia presented with clinical signs of heart failure. Echocardiography revealed a restrictive cardiomyopathy with biventricular thrombi. Hypereosinophilic syndrome resulting in eosinophilic myocarditis (Loeffler's syndrome) was diagnosed. This case highlights the workup, diagnosis, and management of hypereosinophilic syndrome with eosinophilic myocarditis. (Level of Difficulty: Advanced.).

Keywords: CMR, cardiac magnetic resonance imaging; EGPA, eosinophilic granulomatosis with polyangiitis; FISH, fluorescence in situ hybridization; HES, hypereosinophilic syndrome; IL, interleukin; LGE, late gadolinium enhancement; LV, left ventricular; LVEF, left ventricular ejection fraction; Loeffler’s endocarditis; RV, right ventricular; cardiac MRI; cardiomyopathies; eosinophilic myocarditis.

Publication types

Case Reports