GPA-Induced Granulomatous Endocarditis Mimicking a Thrombotic Mitral Valve Stenosis

Christoph Marquetand; Peter Lamprecht; Franz F Dressler; Sven Perner; Konstanze Holl-Ulrich; Ulrich Stierle; Anas Aboud; Jan-Christian Reil

doi:10.1016/j.jaccas.2020.07.053

GPA-Induced Granulomatous Endocarditis Mimicking a Thrombotic Mitral Valve Stenosis

JACC Case Rep. 2020 Oct 14;2(14):2151-2155. doi: 10.1016/j.jaccas.2020.07.053. eCollection 2020 Nov 18.

Authors

Christoph Marquetand¹, Peter Lamprecht², Franz F Dressler³, Sven Perner^{3

4}, Konstanze Holl-Ulrich⁵, Ulrich Stierle⁶, Anas Aboud⁶, Jan-Christian Reil¹

Affiliations

¹ Department of Cardiology, Angiology and Intensive Care, Medical Clinic II, University Heart Center Lübeck, Lübeck, Germany.
² Department of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
³ Institute of Pathology, University Hospital Schleswig-Holstein, Lübeck, Germany.
⁴ Pathology, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
⁵ Pathology Hamburg, MVZ Labor Lademannbogen GmbH, Hamburg, Germany.
⁶ Department of Cardiac and Thoracic Vascular Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

Abstract

We present the case of a patient with granulomatous endocarditis of the mitral valve leading to severe valve stenosis caused by granulomatosis with polyangiitis. Endocarditis is a rare complication of granulomatosis with polyangiitis that may be misdiagnosed as infectious endocarditis or, as in our case, thrombotic lesions. (Level of Difficulty: Intermediate.).

Keywords: ANCA, anti-neutrophil cytoplasmic antibody; GPA, granulomatosis with polyangiitis; IE, infectious endocarditis; MPO, myeloperoxidase; MV, mitral valve; TEE, transesophageal echocardiography; autoimmune; echocardiography; endocarditis; mitral valve; stenosis; thrombosis.

Publication types

Case Reports