Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations

Chaojie Yang; Brian Hallmark; Jin Choul Chai; Timothy D O'Connor; Lindsay M Reynolds; Alexis C Wood; Michael Seeds; Yii-Der Ida Chen; Lyn M Steffen; Michael Y Tsai; Robert C Kaplan; Martha L Daviglus; Lawrence J Mandarino; Amanda M Fretts; Rozenn N Lemaitre; Dawn K Coletta; Sarah A Blomquist; Laurel M Johnstone; Chandra Tontsch; Qibin Qi; Ingo Ruczinski; Stephen S Rich; Rasika A Mathias; Floyd H Chilton; Ani Manichaikul

doi:10.1038/s42003-021-02431-4

Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations

Commun Biol. 2021 Jul 28;4(1):918. doi: 10.1038/s42003-021-02431-4.

Authors

Chaojie Yang^{1

2}, Brian Hallmark³, Jin Choul Chai⁴, Timothy D O'Connor⁵, Lindsay M Reynolds⁶, Alexis C Wood⁷, Michael Seeds⁸, Yii-Der Ida Chen⁹, Lyn M Steffen¹⁰, Michael Y Tsai¹¹, Robert C Kaplan^{4

12}, Martha L Daviglus¹³, Lawrence J Mandarino¹⁴, Amanda M Fretts¹⁵, Rozenn N Lemaitre¹⁶, Dawn K Coletta^{14

17}, Sarah A Blomquist¹⁸, Laurel M Johnstone¹⁹, Chandra Tontsch¹⁸, Qibin Qi⁴, Ingo Ruczinski²⁰, Stephen S Rich¹, Rasika A Mathias²¹, Floyd H Chilton¹⁸, Ani Manichaikul²²

Affiliations

¹ Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
² Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
³ Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA.
⁴ Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
⁵ Institute for Genome Sciences; Program in Personalized and Genomic Medicine; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
⁶ Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake School of Medicine, Winston-Salem, NC, USA.
⁷ USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA.
⁸ Molecular Medicine, Wake Forest University, Winston-Salem, NC, USA.
⁹ Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
¹⁰ Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
¹¹ Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
¹² Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
¹³ Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA.
¹⁴ Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine, Tucson, AZ, USA.
¹⁵ Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
¹⁶ Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
¹⁷ Department of Physiology, University of Arizona College of Medicine, Tucson, AZ, USA.
¹⁸ Department of Nutritional Sciences, University of Arizona College of Agriculture and Life Sciences, Tucson, AZ, USA.
¹⁹ University of Arizona Genetics Core, University of Arizona, Tucson, AZ, USA.
²⁰ Department of Biostatistics, Johns Hopkins University, Baltimore, MD, USA.
²¹ Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
²² Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA. amanicha@virginia.edu.

Abstract

Long chain polyunsaturated fatty acids (LC-PUFAs) have critical signaling roles that regulate dyslipidemia and inflammation. Genetic variation in the FADS gene cluster accounts for a large portion of interindividual differences in circulating and tissue levels of LC-PUFAs, with the genotypes most strongly predictive of low LC-PUFA levels at strikingly higher frequencies in Amerind ancestry populations. In this study, we examined relationships between genetic ancestry and FADS variation in 1102 Hispanic American participants from the Multi-Ethnic Study of Atherosclerosis. We demonstrate strong negative associations between Amerind genetic ancestry and LC-PUFA levels. The FADS rs174537 single nucleotide polymorphism (SNP) accounted for much of the AI ancestry effect on LC-PUFAs, especially for low levels of n-3 LC-PUFAs. Rs174537 was also strongly associated with several metabolic, inflammatory and anthropomorphic traits including circulating triglycerides (TGs) and E-selectin in MESA Hispanics. Our study demonstrates that Amerind ancestry provides a useful and readily available tool to identify individuals most likely to have FADS-related n-3 LC-PUFA deficiencies and associated cardiovascular risk.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Fatty Acid Desaturases / genetics*
Fatty Acid Desaturases / metabolism
Fatty Acids, Omega-3 / deficiency*
Genetic Variation*
Heredity
Hispanic or Latino / genetics*
Humans
Indians, North American / genetics*
Longitudinal Studies
Multigene Family*
United States

Substances

Fatty Acids, Omega-3
Fatty Acid Desaturases

Abstract

Publication types

MeSH terms

Substances

Grants and funding