Laparoscopic liver resection for colorectal liver metastases - short- and long-term outcomes: A systematic review

Emily Taillieu; Celine De Meyere; Frederiek Nuytens; Chris Verslype; Mathieu D'Hondt

doi:10.4251/wjgo.v13.i7.732

Laparoscopic liver resection for colorectal liver metastases - short- and long-term outcomes: A systematic review

World J Gastrointest Oncol. 2021 Jul 15;13(7):732-757. doi: 10.4251/wjgo.v13.i7.732.

Authors

Emily Taillieu¹, Celine De Meyere¹, Frederiek Nuytens¹, Chris Verslype², Mathieu D'Hondt³

Affiliations

¹ Department of Digestive and Hepatobiliary/Pancreatic Surgery, AZ Groeninge, Kortrijk 8500, Belgium.
² Department of Gastroenterology and Hepatology, KU Leuven, Leuven 3000, Belgium.
³ Department of Digestive and Hepatobiliary/Pancreatic Surgery, AZ Groeninge, Kortrijk 8500, Belgium. mathieudhondt2000@yahoo.com.

Abstract

Background: For well-selected patients and procedures, laparoscopic liver resection (LLR) has become the gold standard for the treatment of colorectal liver metastases (CRLM) when performed in specialized centers. However, little is currently known concerning patient-related and peri-operative factors that could play a role in survival outcomes associated with LLR for CRLM.

Aim: To provide an extensive summary of reported outcomes and prognostic factors associated with LLR for CRLM.

Methods: A systematic search was performed in PubMed, EMBASE, Web of Science and the Cochrane Library using the keywords "colorectal liver metastases", "laparoscopy", "liver resection", "prognostic factors", "outcomes" and "survival". Only publications written in English and published until December 2019 were included. Furthermore, abstracts of which no accompanying full text was published, reviews, case reports, letters, protocols, comments, surveys and animal studies were excluded. All search results were saved to Endnote Online and imported in Rayyan for systematic selection. Data of interest were extracted from the included publications and tabulated for qualitative analysis.

Results: Out of 1064 articles retrieved by means of a systematic and grey literature search, 77 were included for qualitative analysis. Seventy-two research papers provided data concerning outcomes of LLR for CRLM. Fourteen papers were eligible for extraction of data concerning prognostic factors affecting survival outcomes. Qualitative analysis of the collected data showed that LLR for CRLM is safe, feasible and provides oncological efficiency. Multiple research groups have reported on the short-term advantages of LLR compared to open procedures. The obtained results accounted for minor LLR, as well as major LLR, simultaneous laparoscopic colorectal and liver resection, LLR of posterosuperior segments, two-stage hepatectomy and repeat LLR for CRLM. Few research groups so far have studied prognostic factors affecting long-term outcomes of LLR for CRLM.

Conclusion: In experienced hands, LLR for CRLM provides good short- and long-term outcomes, independent of the complexity of the procedure.

Keywords: Colorectal liver metastases; Laparoscopic liver resection; Outcomes; Prognostic factors; Systematic review.