Mechanisms of Caloric Restriction-Mediated Stress-Resistance in Acute Kidney Injury

Felix C Koehler; Martin R Späth; K Johanna R Hoyer-Allo; Roman-Ulrich Müller

doi:10.1159/000517733

Mechanisms of Caloric Restriction-Mediated Stress-Resistance in Acute Kidney Injury

Nephron. 2022;146(3):234-238. doi: 10.1159/000517733. Epub 2021 Aug 2.

Authors

Felix C Koehler^{1

2}, Martin R Späth^{1

2}, K Johanna R Hoyer-Allo^{1

2}, Roman-Ulrich Müller^{1

2}

Affiliations

¹ Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
² CECAD, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Abstract

Caloric restriction (CR)-mediated organ protection has been shown to be extremely efficient in rodent models of acute kidney injury (AKI). Limited understanding of the underlying mechanisms paired with a risk of malnourishment and feasibility problems has hindered the translation of this immense potential to the patient setting. In this mini-review, the current mechanistic concepts of CR-mediated stress-resistance as potential key targets for renal protection in AKI will be highlighted.

Keywords: Acute kidney injury; Caloric restriction; Dietary preconditioning; Mechanisms; Stress-resistance.

Publication types

Review

MeSH terms

Acute Kidney Injury* / prevention & control
Caloric Restriction*
Female
Humans
Kidney
Male