Metabolic control of cancer progression as novel targets for therapy

Sarmistha Talukdar; Luni Emdad; Rajan Gogna; Swadesh K Das; Paul B Fisher

doi:10.1016/bs.acr.2021.06.002

Metabolic control of cancer progression as novel targets for therapy

Adv Cancer Res. 2021:152:103-177. doi: 10.1016/bs.acr.2021.06.002. Epub 2021 Jul 12.

Authors

Sarmistha Talukdar¹, Luni Emdad², Rajan Gogna¹, Swadesh K Das², Paul B Fisher³

Affiliations

¹ Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States.
² Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States.
³ Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States. Electronic address: paul.fisher@vcuhealth.org.

PMID: 34353436
DOI: 10.1016/bs.acr.2021.06.002

Abstract

Metabolism is an important part of tumorigenesis as well as progression. The various cancer metabolism pathways, such as glucose metabolism and glutamine metabolism, directly regulate the development and progression of cancer. The pathways by which the cancer cells rewire their metabolism according to their needs, surrounding environment and host tissue conditions are an important area of study. The regulation of these metabolic pathways is determined by various oncogenes, tumor suppressor genes, as well as various constituent cells of the tumor microenvironment. Expanded studies on metabolism will help identify efficient biomarkers for diagnosis and strategies for therapeutic interventions and countering ways by which cancers may acquire resistance to therapy.

Keywords: Cancer; Hypoxia; Metabolism; Therapy; Warburg effect.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Transformation, Neoplastic
Humans
Metabolic Networks and Pathways
Neoplasms* / drug therapy
Neoplasms* / genetics
Oncogenes
Tumor Microenvironment