Cyclic tetrapeptides with sequences related to HC toxin. Conformations and cation binding

Int J Pept Protein Res. 1987 Dec;30(6):801-7. doi: 10.1111/j.1399-3011.1987.tb03389.x.

Abstract

Peptides with sequences related to HC toxin (cyclo(LAla-DAla-L-Aoe-DPro] can adopt a conformation locked by three gamma turns. A "structure--spectroscopy characteristics" relationship is proposed. These peptides can complex Mg++ cations and the binding is accompanied by a transconformation of the peptide backbone. The relevance with the biological activity of the toxin is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Cations
  • Indicators and Reagents
  • Models, Molecular
  • Oligopeptides / chemical synthesis*
  • Peptides, Cyclic / chemical synthesis*
  • Protein Binding
  • Protein Conformation
  • Structure-Activity Relationship
  • Toxins, Biological

Substances

  • Cations
  • Indicators and Reagents
  • Oligopeptides
  • Peptides, Cyclic
  • Toxins, Biological
  • HC toxin