Abstract
Cyclin-dependent kinase 7 (CDK7) is implicated in regulating the expression of cancer-dependent genes, and multiple CDK7-targeted therapies are currently under clinical investigation. Three recent studies elucidate the structure of human transcription machinery, offering vital mechanistic insights into CDK7 function and a potential pharmacodynamic marker of CDK7 activity in tumors.
Copyright © 2021 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Cyclin-Dependent Kinase-Activating Kinase
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Cyclin-Dependent Kinases / chemistry
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Cyclin-Dependent Kinases / genetics*
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Gene Expression Regulation, Neoplastic / drug effects
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Gene Regulatory Networks / drug effects
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Humans
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Mice
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Models, Molecular
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Neoplasms / drug therapy
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Neoplasms / genetics*
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Precision Medicine
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Small Molecule Libraries / pharmacology*
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Small Molecule Libraries / therapeutic use
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Transcription, Genetic / drug effects
Substances
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Small Molecule Libraries
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Cyclin-Dependent Kinases
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Cyclin-Dependent Kinase-Activating Kinase