Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants

Shuo Du; Pulan Liu; Zhiying Zhang; Tianhe Xiao; Ayijiang Yasimayi; Weijin Huang; Youchun Wang; Yunlong Cao; Xiaoliang Sunney Xie; Junyu Xiao

doi:10.1038/s41422-021-00555-0

Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants

Cell Res. 2021 Oct;31(10):1130-1133. doi: 10.1038/s41422-021-00555-0. Epub 2021 Aug 25.

Authors

Shuo Du^#^{1

2}, Pulan Liu^#^{1

2}, Zhiying Zhang^#^{1

2}, Tianhe Xiao^{2

3

4}, Ayijiang Yasimayi^{2

3

4}, Weijin Huang⁵, Youchun Wang⁵, Yunlong Cao^{6

7}, Xiaoliang Sunney Xie^{8

9

10

11}, Junyu Xiao^{12

13

14

15}

Affiliations

¹ State Key Laboratory of Protein and Plant Gene Research, Peking University, Beijing, China.
² School of Life Sciences, Peking University, Beijing, China.
³ Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China.
⁴ Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China.
⁵ Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, China.
⁶ Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China. yunlongcao@pku.edu.cn.
⁷ Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China. yunlongcao@pku.edu.cn.
⁸ School of Life Sciences, Peking University, Beijing, China. sunneyxie@biopic.pku.edu.cn.
⁹ Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China. sunneyxie@biopic.pku.edu.cn.
¹⁰ Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China. sunneyxie@biopic.pku.edu.cn.
¹¹ Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. sunneyxie@biopic.pku.edu.cn.
¹² State Key Laboratory of Protein and Plant Gene Research, Peking University, Beijing, China. junyuxiao@pku.edu.cn.
¹³ School of Life Sciences, Peking University, Beijing, China. junyuxiao@pku.edu.cn.
¹⁴ Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China. junyuxiao@pku.edu.cn.
¹⁵ Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. junyuxiao@pku.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Angiotensin-Converting Enzyme 2 / chemistry
Angiotensin-Converting Enzyme 2 / metabolism
Antibodies, Monoclonal / chemistry
Antibodies, Monoclonal / immunology
Antibodies, Neutralizing / chemistry
Antibodies, Neutralizing / immunology*
Binding Sites
COVID-19 / pathology
COVID-19 / virology
Cryoelectron Microscopy
Humans
Molecular Dynamics Simulation
Protein Binding
Protein Domains / immunology
SARS-CoV-2 / isolation & purification
SARS-CoV-2 / metabolism*
Spike Glycoprotein, Coronavirus / chemistry
Spike Glycoprotein, Coronavirus / immunology*

Substances

Antibodies, Monoclonal
Antibodies, Neutralizing
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2
ACE2 protein, human
Angiotensin-Converting Enzyme 2

Grants and funding

31822014/National Natural Science Foundation of China (National Science Foundation of China)