New-onset autoimmune hepatitis following mRNA COVID-19 vaccination in a 36-year-old woman with primary sclerosing cholangitis - should we be more vigilant?

J Hepatol. 2022 Jan;76(1):218-220. doi: 10.1016/j.jhep.2021.08.006. Epub 2021 Aug 25.

Authors

Taotao Zhou¹, Florian Fronhoffs², Leona Dold¹, Christian P Strassburg¹, Tobias J Weismüller³

Affiliations

¹ Department of Internal Medicine 1, University Hospital Bonn, Bonn, Germany.
² Institute of Pathology, University Hospital Bonn, Bonn, Germany.
³ Department of Internal Medicine 1, University Hospital Bonn, Bonn, Germany. Electronic address: Tobias.Weismueller@gmx.de.

No abstract available

Keywords: Autoimmune Hepatitis; COVID 19-Vaccination; Primary Sclerosing Cholangitis.

Publication types

Case Reports
Letter

MeSH terms

2019-nCoV Vaccine mRNA-1273* / administration & dosage
2019-nCoV Vaccine mRNA-1273* / adverse effects
Adult
Alanine Transaminase / blood
Antibodies, Antinuclear / blood
Aspartate Aminotransferases / blood
COVID-19 Vaccines / administration & dosage
COVID-19 Vaccines / adverse effects
COVID-19* / epidemiology
COVID-19* / prevention & control
Cholangitis, Sclerosing* / blood
Cholangitis, Sclerosing* / diagnosis
Cholangitis, Sclerosing* / physiopathology
Cholangitis, Sclerosing* / therapy
Female
Glucocorticoids / administration & dosage
Hepatitis, Autoimmune* / etiology
Hepatitis, Autoimmune* / immunology
Hepatitis, Autoimmune* / therapy
Humans
Liver / pathology
Prednisolone / administration & dosage*
SARS-CoV-2
Treatment Outcome

Substances

Antibodies, Antinuclear
COVID-19 Vaccines
Glucocorticoids
anti-dsDNA autoantibody
Prednisolone
Aspartate Aminotransferases
Alanine Transaminase
2019-nCoV Vaccine mRNA-1273