Post-severe Acute Respiratory Syndrome Coronavirus 2 Monoclonal Antibody Treatment Hospitalizations as a Sentinel for Emergence of Viral Variants in New York City

Kelsie Cowman; Yi Guo; Liise-Anne Pirofski; David Wong; Hongkai Bao; Victor Chen; Una Hopkins; Erin Andrews; Joseph Hamel; Marla Keller; Eran Bellin; Raja Thota; Patricia Davis; Edwin Torres Rodriguez; Pooja Suthar; Lauren Allen; James Rossi; Adam Haviland; Erika Orner; Wendy Szymczak; Sadahf Shujauddin; James McCarthy; Barbara Binder; Vanitha Pushparaj; Linda Bard; Vincent Frank Pierino; Leslie Alsina; David Esses; Alicia McCaskie; Caron Campbell; Tabitha Madzura; Andrew Wollowitz; Kelly Basset; Deborah White; Rafael Ruiz; Frank Sosnowski; Priya Nori

doi:10.1093/ofid/ofab313

Post-severe Acute Respiratory Syndrome Coronavirus 2 Monoclonal Antibody Treatment Hospitalizations as a Sentinel for Emergence of Viral Variants in New York City

Open Forum Infect Dis. 2021 Jun 12;8(8):ofab313. doi: 10.1093/ofid/ofab313. eCollection 2021 Aug.

Authors

Kelsie Cowman¹, Yi Guo², Liise-Anne Pirofski^{1

3}, David Wong⁴, Hongkai Bao², Victor Chen², Una Hopkins⁵, Erin Andrews⁶, Joseph Hamel⁷, Marla Keller¹, Eran Bellin⁸, Raja Thota⁶, Patricia Davis⁵, Edwin Torres Rodriguez⁹, Pooja Suthar², Lauren Allen², James Rossi¹, Adam Haviland¹, Erika Orner¹⁰, Wendy Szymczak¹⁰, Sadahf Shujauddin¹¹, James McCarthy¹², Barbara Binder¹², Vanitha Pushparaj¹³, Linda Bard¹³, Vincent Frank Pierino¹³, Leslie Alsina¹³, David Esses¹⁴, Alicia McCaskie¹⁴, Caron Campbell¹⁴, Tabitha Madzura¹⁴, Andrew Wollowitz¹⁴, Kelly Basset¹⁴, Deborah White¹⁴, Rafael Ruiz⁶, Frank Sosnowski², Priya Nori¹

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.
² Department of Pharmacy, Montefiore Medical Center, Bronx, New York, USA.
³ Department of Microbiology and Immunology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA.
⁴ Medical Officer, COVID-19 Therapeutics Team, US Department of Health and Human Services, Rockville, MD, USA.
⁵ Department of Nursing, Montefiore Medical Center, Bronx, New York, USA.
⁶ Network Performance Group, Montefiore Medical Center, Bronx, New York, USA.
⁷ Office of Strategy, Planning, Policy and Requirements, Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, Washington, DC, USA.
⁸ Department of Epidemiology, Population Health and Medicine Albert Einstein College of Medicine, Montefiore Health System, Bronx, New York, USA.
⁹ Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.
¹⁰ Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
¹¹ Department of Pediatric Cardiology, Children's Hospital at Montefiore, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.
¹² Department of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA.
¹³ Faculty Practice Group, Montefiore Health System, Bronx, New York, USA.
¹⁴ Department of Emergency Medicine Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA.

Abstract

We partnered with the US Department of Health and Human Services to treat high-risk, nonadmitted coronavirus disease 2019 (COVID-19) patients with bamlanivimab in the Bronx, New York per Emergency Use Authorization criteria. Increasing posttreatment hospitalizations were observed monthly between December 2020 and March 2021 in parallel to the emergence of severe acute respiratory syndrome coronavirus 2 variants in New York City.

Keywords: COVID-19; SARS-CoV-2 variants; antimicrobial stewardship; monoclonal antibodies.

Abstract

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