Bisulfite Addition Compounds as Substrates for Reductive Aminations in Water

Org Lett. 2021 Sep 17;23(18):7205-7208. doi: 10.1021/acs.orglett.1c02604. Epub 2021 Sep 2.

Abstract

Highly valued products resulting from reductive aminations utilizing shelf-stable bisulfite addition compounds of aldehydes can be made under aqueous micellar catalysis conditions. Readily available α-picolineborane serves as the stoichiometric hydride source. Recycling of the aqueous reaction medium is easily accomplished, and several applications to targets in the pharmaceutical industry are documented.

Publication types

  • Research Support, Non-U.S. Gov't