Intravoxel incoherent motion diffusion-weighted imaging in the characterization of Alzheimer's disease

Abstract

Objectives: Alzheimer's disease (AD) is the most common type of dementia, and characterizing brain changes in AD is important for clinical diagnosis and prognosis. This study was designed to evaluate the classification performance of intravoxel incoherent motion (IVIM) diffusion-weighted imaging in differentiating between AD patients and normal control (NC) subjects and to explore its potential effectiveness as a neuroimaging biomarker.

Methods: Thirty-one patients with probable AD and twenty NC subjects were included in the prospective study. IVIM data were subjected to postprocessing, and parameters including the apparent diffusion coefficient (ADC), slow diffusion coefficient (D_s), fast diffusion coefficient (D_f), perfusion fraction (fp) and D_f*fp were calculated. The classification model was developed and confirmed with cross-validation (group A/B) using Support Vector Machine (SVM). Correlations between IVIM parameters and Mini-Mental State Examination (MMSE) scores in AD patients were investigated using partial correlation analysis.

Results: Diffusion MRI revealed significant region-specific differences that aided in differentiating AD patients from controls. Among the analyzed regions and parameters, the D_f of the right precuneus (PreR) (ρ = 0.515; P = 0.006) and the left cerebellum (CL) (ρ = 0.429; P = 0.026) demonstrated significant associations with the cognitive function of AD patients. An area under the receiver operating characteristics curve (AUC) of 0.84 (95% CI: 0.66, 0.99) was calculated for the validation in dataset B after the prediction model was trained on dataset A. When the datasets were reversed, an AUC of 0.90 (95% CI: 0.75, 1.00) was calculated for the validation in dataset A, after the prediction model trained in dataset B.

Conclusion: IVIM imaging is a promising method for the classification of AD and NC subjects, and IVIM parameters of precuneus and cerebellum might be effective biomarker for the diagnosis of AD.

Keywords: Alzheimer’s disease; Cross-validation; Diffusion; Intravoxel incoherent motion; Precuneus.