Endotoxin and Cytokine Sequential Hemoadsorption in Septic Shock and Multi-Organ Failure

Blood Purif. 2022;51(7):630-633. doi: 10.1159/000518229. Epub 2021 Sep 7.

Abstract

The mortality of septic shock remains high [Ann Intensive Care. 2017;7:19], so apart from usual therapy based on source control and antibiotics, some patients may need rescue therapies. Blood purification systems may play a role by facilitating the nonspecific removal of inflammatory mediators and microbiological toxins. There are different hemoadsorption systems, we describe in this case report the sequential use of Polymyxin B (PMX) endotoxin-adsorbing column (Toraymixin PMX-20R; Toray, Tokyo, Japan) and Cytosorb® (Cytosorbents Corp., New Jersey, USA).

Keywords: Endotoxin hemoadsorption; Polymyxin B hemoadsorption; Septic shock.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Cytokines
  • Endotoxins
  • Hemoperfusion*
  • Humans
  • Multiple Organ Failure / therapy
  • Polymyxin B / therapeutic use
  • Shock, Septic*

Substances

  • Anti-Bacterial Agents
  • Cytokines
  • Endotoxins
  • Polymyxin B