Can we trust in Sars-CoV-2 rapid antigen testing? Preliminary results from a paediatric cohort in the emergency department

Ir J Med Sci. 2022 Aug;191(4):1767-1770. doi: 10.1007/s11845-021-02776-z. Epub 2021 Sep 14.

Abstract

Background: Rapid identification of Covid-19 in the paediatric emergency department is critical; Antigen tests are fast but poorly investigated in children.

Aims: To investigate Sars-CoV-2 antigen rapid test in children.

Methods: We compare the performance of LumiraDx with molecular tests in a paediatric emergency department.

Results: A retrospective cohort of 191 patients with AT and PCR tests performed in the same episode was analysed; 16% resulted positive for Sars-CoV-2. Using the PCR test as the gold standard, we calculated antigen testing overall sensitivity of 94.1%, specificity of 91.9%, and NPV of 99.4%. Only one false-negative test was found.

Conclusions: AT may be helpful in the initial screening of patients at PED.

Keywords: Antigen tests; COVID-19; Emergency department; Point-of-care tests; Sars-Cov-2.

MeSH terms

  • COVID-19* / diagnosis
  • Child
  • Emergency Service, Hospital
  • Humans
  • Retrospective Studies
  • SARS-CoV-2*
  • Sensitivity and Specificity