1 Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston (UT Health), Houston, Texas.
2 Department of Life Science, University of Toronto, Toronto, Canada.
3 Department of Biostatistics, School of Public Health, University of Texas Health Science Center at Houston (UT Health), Houston, Texas.
4 Department of Anesthesiology, University of Toronto, University Health Network, Toronto, Canada.
5 Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston (UT Health), Houston, Texas, george.w.williams@uth.tmc.edu.