Gastrointestinal stromal tumours: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up

P G Casali; J Y Blay; N Abecassis; J Bajpai; S Bauer; R Biagini; S Bielack; S Bonvalot; I Boukovinas; J V M G Bovee; K Boye; T Brodowicz; A Buonadonna; E De Álava; A P Dei Tos; X G Del Muro; A Dufresne; M Eriksson; A Fedenko; V Ferraresi; A Ferrari; A M Frezza; S Gasperoni; H Gelderblom; F Gouin; G Grignani; R Haas; A B Hassan; N Hindi; P Hohenberger; H Joensuu; R L Jones; C Jungels; P Jutte; B Kasper; A Kawai; K Kopeckova; D A Krákorová; A Le Cesne; F Le Grange; E Legius; A Leithner; A Lopez-Pousa; J Martin-Broto; O Merimsky; C Messiou; A B Miah; O Mir; M Montemurro; C Morosi; E Palmerini; M A Pantaleo; R Piana; S Piperno-Neumann; P Reichardt; P Rutkowski; A A Safwat; C Sangalli; M Sbaraglia; S Scheipl; P Schöffski; S Sleijfer; D Strauss; S J Strauss; K Sundby Hall; A Trama; M Unk; M A J van de Sande; W T A van der Graaf; W J van Houdt; T Frebourg; A Gronchi; S Stacchiotti; ESMO Guidelines Committee, EURACAN and GENTURIS. Electronic address: clinicalguidelines@esmo.org

doi:10.1016/j.annonc.2021.09.005

Gastrointestinal stromal tumours: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up

Ann Oncol. 2022 Jan;33(1):20-33. doi: 10.1016/j.annonc.2021.09.005. Epub 2021 Sep 21.

Authors

P G Casali¹, J Y Blay², N Abecassis³, J Bajpai⁴, S Bauer⁵, R Biagini⁶, S Bielack⁷, S Bonvalot⁸, I Boukovinas⁹, J V M G Bovee¹⁰, K Boye¹¹, T Brodowicz¹², A Buonadonna¹³, E De Álava¹⁴, A P Dei Tos¹⁵, X G Del Muro¹⁶, A Dufresne¹⁷, M Eriksson¹⁸, A Fedenko¹⁹, V Ferraresi²⁰, A Ferrari²¹, A M Frezza²², S Gasperoni²³, H Gelderblom²⁴, F Gouin²⁵, G Grignani²⁶, R Haas²⁷, A B Hassan²⁸, N Hindi²⁹, P Hohenberger³⁰, H Joensuu³¹, R L Jones³², C Jungels³³, P Jutte³⁴, B Kasper³⁰, A Kawai³⁵, K Kopeckova³⁶, D A Krákorová³⁷, A Le Cesne³⁸, F Le Grange³⁹, E Legius⁴⁰, A Leithner⁴¹, A Lopez-Pousa⁴², J Martin-Broto²⁹, O Merimsky⁴³, C Messiou⁴⁴, A B Miah⁴⁵, O Mir⁴⁶, M Montemurro⁴⁷, C Morosi⁴⁸, E Palmerini⁴⁹, M A Pantaleo⁵⁰, R Piana⁵¹, S Piperno-Neumann⁵², P Reichardt⁵³, P Rutkowski⁵⁴, A A Safwat⁵⁵, C Sangalli⁵⁶, M Sbaraglia¹⁵, S Scheipl⁴¹, P Schöffski⁵⁷, S Sleijfer⁵⁸, D Strauss⁵⁹, S J Strauss³⁹, K Sundby Hall¹¹, A Trama⁶⁰, M Unk⁶¹, M A J van de Sande⁶², W T A van der Graaf⁶³, W J van Houdt⁶⁴, T Frebourg⁶⁵, A Gronchi⁶⁶, S Stacchiotti²²; ESMO Guidelines Committee, EURACAN and GENTURIS. Electronic address: clinicalguidelines@esmo.org

Affiliations

¹ Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; Department of Oncology and Hemato-oncology University of Milan, Milan, Italy.
² Centre Leon Berard and UCBL1, Lyon, France.
³ Instituto Portugues de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal.
⁴ Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
⁵ Department of Medical Oncology, Interdisciplinary Sarcoma Center, West German Cancer Center, University of Duisburg-Essen, Essen, Germany.
⁶ Department of Oncological Orthopedics, Musculoskeletal Tissue Bank, IFO, Regina Elena National Cancer Institute, Rome, Italy.
⁷ Klinikum Stuttgart-Olgahospital, Stuttgart, Germany.
⁸ Department of Surgery, Institut Curie, Paris, France.
⁹ Bioclinic Thessaloniki, Thessaloniki, Greece.
¹⁰ Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
¹¹ Department of Oncology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway.
¹² Vienna General Hospital (AKH), Medizinische Universität Wien, Vienna, Austria.
¹³ Centro di Riferimento Oncologico di Aviano, Aviano, Italy.
¹⁴ Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital/CSIC/University of Sevilla/CIBERONC, Seville, Spain; Department of Normal and Pathological Cytology and Histology, School of Medicine, University of Seville, Seville, Spain.
¹⁵ Department of Pathology, Azienda Ospedale Università Padova, Padova, Italy.
¹⁶ Integrated Unit ICO Hospitalet, HUB, Barcelona, Spain.
¹⁷ Département d'Oncologie Médicale, Centre Leon Berard, Lyon, France.
¹⁸ Skane University Hospital-Lund, Lund, Sweden.
¹⁹ P. A. Herzen Cancer Research Institute, Moscow, Russian Federation.
²⁰ Sarcomas and Rare Tumors Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
²¹ Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
²² Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
²³ Department of Oncology and Robotic Surgery, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.
²⁴ Department of Medical Oncology, Leiden University Medical Centre, Leiden, The Netherlands.
²⁵ Centre Leon-Berard Lyon, Lyon, France.
²⁶ Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy.
²⁷ Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Department of Radiotherapy, Leiden University Medical Centre, Leiden, The Netherlands.
²⁸ Oxford University Hospitals NHS Foundation Trust and University of Oxford, Oxford, UK.
²⁹ Department of Medical Oncology, Fundación Jimenez Diaz, University Hospital, Advanced Therapies in Sarcoma Lab, Madrid, Spain.
³⁰ Mannheim University Medical Center, Mannheim, Germany.
³¹ Helsinki University Hospital (HUH) and University of Helsinki, Helsinki, Finland.
³² Sarcoma Unit, Royal Marsden Hospital and Institute of Cancer Research, London, UK.
³³ Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
³⁴ University Medical Center Groningen, Groningen, The Netherlands.
³⁵ Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo, Japan.
³⁶ University Hospital Motol, Prague, Czech Republic.
³⁷ Masaryk Memorial Cancer Institute, Brno, Czech Republic.
³⁸ Department of Cancer Medicine, Gustave Roussy, Villejuif, France.
³⁹ Department of Oncology, University College London Hospitals NHS Foundation Trust (UCLH), London, UK.
⁴⁰ Department for Human Genetics, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
⁴¹ Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria.
⁴² Medical Oncology Department, Hospital Universitario Santa Creu i Sant Pau, Barcelona, Spain.
⁴³ Aviv Sourasky Medical Center (Ichilov), Tel Aviv, Israel.
⁴⁴ Department of Radiology, Royal Marsden Hospital and Institute of Cancer Research, London, UK.
⁴⁵ Department of Oncology, Royal Marsden Hospital and Institute of Cancer Research, London, UK.
⁴⁶ Department of Ambulatory Cancer Care, Gustave Roussy, Villejuif, France.
⁴⁷ Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
⁴⁸ Department of Radiology, IRCCS Foundation National Cancer Institute, Milan, Italy.
⁴⁹ Department of Osteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
⁵⁰ Division of Oncology, IRCCS Azienda Ospedaliero-Universitaria, di Bologna, Bologna, Italy.
⁵¹ Azienda Ospedaliero, Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
⁵² Department of Medical Oncology, Institut Curie, Paris, France.
⁵³ Helios Klinikum Berlin Buch, Berlin, Germany.
⁵⁴ Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
⁵⁵ Aarhus University Hospital, Aarhus, Denmark.
⁵⁶ Department of Radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
⁵⁷ Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.
⁵⁸ Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
⁵⁹ Department of Surgery, Royal Marsden Hospital, London, UK.
⁶⁰ Department of Research, Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
⁶¹ Institute of Oncology of Ljubljana, Ljubljana, Slovenia.
⁶² Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, The Netherlands.
⁶³ Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands; Department of Medical Oncology, the Netherlands Cancer Institute, Amsterdam, The Netherlands.
⁶⁴ Department of Surgical Oncology, the Netherlands Cancer Institute, Amsterdam, The Netherlands.
⁶⁵ Department of Genetics, Normandy Center for Genomic and Personalized Medicine, Normandie University, UNIROUEN, Inserm U1245 and Rouen University Hospital, Rouen, France.
⁶⁶ Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori and University of Milan, Milan, Italy.

PMID: 34560242
DOI: 10.1016/j.annonc.2021.09.005

No abstract available

Keywords: GIST; clinical practice guidelines; gastrointestinal stromal tumour; surgery; tyrosine kinase inhibitor.

Publication types

Practice Guideline
Research Support, Non-U.S. Gov't

MeSH terms

Follow-Up Studies
Gastrointestinal Neoplasms* / diagnosis
Gastrointestinal Neoplasms* / epidemiology
Gastrointestinal Neoplasms* / therapy
Gastrointestinal Stromal Tumors* / diagnosis
Gastrointestinal Stromal Tumors* / epidemiology
Gastrointestinal Stromal Tumors* / therapy
Humans
Sarcoma* / therapy