The GH-IGF-1 Axis in Circadian Rhythm

Weihao Wang; Xiaoye Duan; Zhengxiang Huang; Qi Pan; Chen Chen; Lixin Guo

doi:10.3389/fnmol.2021.742294

The GH-IGF-1 Axis in Circadian Rhythm

Front Mol Neurosci. 2021 Sep 9:14:742294. doi: 10.3389/fnmol.2021.742294. eCollection 2021.

Authors

Weihao Wang¹, Xiaoye Duan¹, Zhengxiang Huang², Qi Pan¹, Chen Chen², Lixin Guo¹

Affiliations

¹ Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
² School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.

Abstract

Organisms have developed common behavioral and physiological adaptations to the influence of the day/night cycle. The CLOCK system forms an internal circadian rhythm in the suprachiasmatic nucleus (SCN) during light/dark input. The SCN may synchronize the growth hormone (GH) secretion rhythm with the dimming cycle through somatostatin neurons, and the change of the clock system may be related to the pulsatile release of GH. The GH-insulin-like growth factor 1 (IGF-1) axis and clock system may interact further on the metabolism through regulatory pathways in peripheral organs. We have summarized the current clinical and animal evidence on the interaction of clock systems with the GH-IGF-1 axis and discussed their effects on metabolism.

Keywords: GH; IGF-1; circadian rhythm; clock; metabolism.

Publication types

Review