"Ways in which the neonatal Fc-receptor is involved in autoimmunity"

Abstract

Since the neonatal IgG Fc receptor (FcRn) was discovered, its role has evolved from immunoglobulin recycling and biodistribution to antigen presentation and immune complex routing, bringing it to the center of both humoral and cellular immune responses. FcRn is thus involved in the pathophysiology of immune-related diseases such as cancer, infection, and autoimmune disorders. This review focuses on the role of FcRn in autoimmunity, based on the available data from both animal models and human studies. The knowledge concerning ways in which FcRn is involved in autoimmune response has led to the development of inhibitors for the treatment of autoimmune diseases, also described here. Up to date, the literature remains scarce, shedding light on the need for further studies to fully understand the various pathophysiological roles of this unique receptor.

Keywords: Autoimmune disease; Autoimmunity; FcRn, Neonatal Fc receptor; IC, Immune complexes; Monoclonal therapeutic antibodies; Neonatal Fc receptor; mAbs, Monoclonal antibodies.