Constitutively Activating GNAS Somatic Mutation in Right Ventricular Outflow Tract Tachycardia

Circ Arrhythm Electrophysiol. 2021 Oct;14(10):e010082. doi: 10.1161/CIRCEP.121.010082. Epub 2021 Sep 30.

James E Ip¹, Linna Xu¹, Jie Dai¹, Clemens Steegborn^{2

3}, Fabrice Jaffré⁴, Todd Evans⁴, Jim W Cheung¹, Craig T Basson^{1

5}, Gianina Panaghie¹, Trine Krogh-Madsen¹, Geoffrey W Abbott^{1

6}, Bruce B Lerman¹

¹ Division of Cardiology, Department of Medicine, Cornell University Medical Center, New York (J.E.I., L.X., J.D., J.W.C., C.T.B., G.P., T.K.-M., G.W.A., B.B.L.).
² Department of Biochemistry, Weill-Cornell Medical College, New York (C.S.).
³ Now with Department of Biochemistry, University of Bayreuth, Germany (C.S.).
⁴ Department of Surgery, Weill-Cornell Medical College, New York (F.J., T.E.).
⁵ Now with Boston Pharmaceuticals, Cambridge, MA (C.T.B.).
⁶ Now with Department of Physiology and Biophysics, University of California, Irvine (G.W.A.).

Abstract

[Figure: see text].

Keywords: GTP-binding proteins; arrhythmia; mutation; signal transduction; tachycardia, ventricular.