Phenolic constituents from twigs of Aleurites fordii and their biological activities

Kyoung Jin Park; Won Se Suh; Da Hye Yoon; Chung Sub Kim; Sun Yeou Kim; Kang Ro Lee

doi:10.3762/bjoc.17.151

Phenolic constituents from twigs of Aleurites fordii and their biological activities

Beilstein J Org Chem. 2021 Sep 7:17:2329-2339. doi: 10.3762/bjoc.17.151. eCollection 2021.

Authors

Kyoung Jin Park^#¹, Won Se Suh^#¹, Da Hye Yoon², Chung Sub Kim^{1

3}, Sun Yeou Kim², Kang Ro Lee¹

Affiliations

¹ Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
² Laboratory of Pharmacognosy, College of Pharmacy, Gachon University, Incheon, 21936, Republic of Korea.
³ Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea.

^# Contributed equally.

Abstract

Three new neolignan glycosides (1-3), a new phenolic glycoside (15), and a new cyanoglycoside (16) were isolated and characterized from the twigs of Aleurites fordii together with 14 known analogues (4-14 and 17-19). The structural elucidation of the new compounds was performed through the analysis of their NMR, HRMS, and ECD spectra and by chemical methods. All isolated compounds were tested for their antineuroinflammatory and neuroprotective activities.

Keywords: Aleurites fordii; Euphorbiaceae; antineuroinflammation; neolignan glycoside; neuroprotective activity; phenolic compound.

Grants and funding

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology (2016R1A2B2008380).