Abstract
New nanoparticles (Y6 NPs) based on the A-DA'D-A fused-ring conjugated small molecule Y6 have been prepared for the combined photothermal and photodynamic therapy of cancer. Y6 NPs show excellent light absorption from 300 to 900 nm, a good photothermal conversion efficiency of 57% and reactive oxygen species generation capability. The high photothermal conversion ability and superior photodynamic activity of Y6 NPs endow them with great potential for cancer therapy.
MeSH terms
-
Animals
-
Antineoplastic Agents / chemical synthesis
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Drug Screening Assays, Antitumor
-
Humans
-
Mice
-
Nanoparticles* / chemistry
-
Neoplasms / drug therapy
-
Photochemotherapy*
-
Photosensitizing Agents* / chemical synthesis
-
Photosensitizing Agents* / chemistry
-
Photosensitizing Agents* / pharmacology
-
Photothermal Therapy
-
Reactive Oxygen Species* / metabolism
-
Small Molecule Libraries / chemical synthesis
-
Small Molecule Libraries / chemistry
-
Small Molecule Libraries / pharmacology
Substances
-
Photosensitizing Agents
-
Reactive Oxygen Species
-
Antineoplastic Agents
-
Small Molecule Libraries