Heavy mutagenesis by tobacco leads to lung adenocarcinoma tumors with KRAS G12 mutations other than G12D, leading KRAS G12D tumors-on average-to exhibit a lower mutation burden

Lung Cancer. 2022 Apr:166:265-269. doi: 10.1016/j.lungcan.2021.10.008. Epub 2021 Oct 28.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adenocarcinoma of Lung* / genetics
  • Adenocarcinoma* / genetics
  • Adenocarcinoma* / pathology
  • Humans
  • Lung Neoplasms* / genetics
  • Lung Neoplasms* / pathology
  • Mutagenesis
  • Mutation
  • Nicotiana
  • Proto-Oncogene Proteins p21(ras) / genetics

Substances

  • KRAS protein, human
  • Proto-Oncogene Proteins p21(ras)