Ascending Aneurysms in Heart Transplant Patients: A Rare Opportunity to Assess Heredity Versus Biological Environment

Osama Anis; Gary S Kopf; Bulat A Ziganshin; Mohammad A Zafar; Maryann Tranquilli; Richard Sieller; John A Elefteriades

doi:10.1016/j.jaccas.2021.07.010

Ascending Aneurysms in Heart Transplant Patients: A Rare Opportunity to Assess Heredity Versus Biological Environment

JACC Case Rep. 2021 Nov 3;3(15):1685-1689. doi: 10.1016/j.jaccas.2021.07.010.

Authors

Osama Anis¹, Gary S Kopf¹, Bulat A Ziganshin^{1

2}, Mohammad A Zafar¹, Maryann Tranquilli¹, Richard Sieller¹, John A Elefteriades¹

Affiliations

¹ Aortic Institute at Yale-New Haven, Yale University School of Medicine, New Haven, Connecticut, USA.
² Department of Cardiovascular and Endovascular Surgery, Kazan State Medical University, Kazan, Russia.

Abstract

Three patients developed severe ascending aortic aneurysm requiring surgical resection after heart transplantation. In all 3 cases, the donor aorta of the transplant remained normal in caliber, despite the development of a large aneurysm in the native upper ascending aorta. The aneurysmal disease did not cross the suture line. (Level of Difficulty: Advanced.).

Keywords: TGF, transforming growth factor; aorta; dissection; genetics.

Publication types

Case Reports