MALDI-MS: Emerging roles in pathology and laboratory medicine

Mark Duncan; Mari L DeMarco

doi:10.1016/j.clinms.2019.05.003

MALDI-MS: Emerging roles in pathology and laboratory medicine

Clin Mass Spectrom. 2019 May 18:13:1-4. doi: 10.1016/j.clinms.2019.05.003. eCollection 2019 Aug.

Authors

Mark Duncan¹, Mari L DeMarco^{2

3}

Affiliations

¹ Biodesix Inc., Boulder, CO, USA.
² Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
³ Department of Pathology and Laboratory Medicine, St. Paul's Hospital, Providence Health Care, Vancouver, Canada.

Abstract

•MALDI-MS is a valuable analytical tool in pathology and laboratory medicine.•Advantages of MALDI-MS include ease of sample preparation and analysis.•Uses include ID of pathogens, monoclonal proteins, variants and diseased tissue.

Keywords: CLIP, corticotropin-like intermediate lobe peptide; Diagnostics; Genotyping; LC-MS/MS, liquid chromatography tandem mass spectrometry; MALDI, matrix-assisted laser desorption/ionization; MS, mass spectrometry; MSI, mass spectrometry imaging; Mass spectrometry; Matrix-assisted laser desorption/ionization; Medicine; Protein; TOF, time of flight; Tissue imaging.

Publication types

Review