Baicalein is a novel TLR4-targeting therapeutics agent that inhibits TLR4/HIF-1α/VEGF signaling pathway in colorectal cancer

Clin Transl Med. 2021 Nov;11(11):e564. doi: 10.1002/ctm2.564.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Hormonal / metabolism
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Colorectal Neoplasms / drug therapy
  • Colorectal Neoplasms / physiopathology
  • Flavanones / pharmacology*
  • Flavanones / therapeutic use
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / drug effects*
  • Signal Transduction / drug effects
  • Tamoxifen / metabolism
  • Tamoxifen / therapeutic use
  • Toll-Like Receptor 4 / drug effects*
  • Vascular Endothelial Growth Factor A / drug effects*

Substances

  • Antineoplastic Agents, Hormonal
  • Flavanones
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • TLR4 protein, human
  • Toll-Like Receptor 4
  • Vascular Endothelial Growth Factor A
  • Tamoxifen
  • baicalein