Central Nervous System Effects of COVID-19 in People with HIV Infection

Curr HIV/AIDS Rep. 2021 Dec;18(6):538-548. doi: 10.1007/s11904-021-00582-x. Epub 2021 Nov 29.

Abstract

The convergence of the HIV and SARS-CoV-2 pandemics is an emerging field of interest. In this review, we outline the central nervous system (CNS) effects of COVID-19 in the general population and how these effects may manifest in people with HIV (PWH). We discuss the hypothetical mechanisms through which SARS-CoV-2 could impact the CNS during both the acute and recovery phases of infection and the potential selective vulnerability of PWH to these effects as a result of epidemiologic, clinical, and biologic factors. Finally, we define key research questions and considerations for the investigation of CNS sequelae of COVID-19 in PWH.

Keywords: COVID-19; Central nervous system; HIV; SARS-CoV-2.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • COVID-19*
  • Central Nervous System
  • HIV Infections* / complications
  • HIV Infections* / epidemiology
  • Humans
  • Pandemics
  • SARS-CoV-2