A Higher Antibody Response Is Generated With a 6- to 7-Week (vs Standard) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Dosing Interval

Brian Grunau; Michael Asamoah-Boaheng; Pascal M Lavoie; Mohammad Ehsanul Karim; Tracy L Kirkham; Paul A Demers; Vilte Barakauskas; Ana Citlali Marquez; Agatha N Jassem; Sheila F O'Brien; Steven J Drews; Scott Haig; Sheldon Cheskes; David M Goldfarb

doi:10.1093/cid/ciab938

A Higher Antibody Response Is Generated With a 6- to 7-Week (vs Standard) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Dosing Interval

Clin Infect Dis. 2022 Aug 24;75(1):e888-e891. doi: 10.1093/cid/ciab938.

Authors

Brian Grunau^{1

2

3}, Michael Asamoah-Boaheng^{2

4}, Pascal M Lavoie⁵, Mohammad Ehsanul Karim^{1

6}, Tracy L Kirkham^{7

8}, Paul A Demers^{6

7

8}, Vilte Barakauskas⁹, Ana Citlali Marquez^{9

10}, Agatha N Jassem^{9

10}, Sheila F O'Brien¹¹, Steven J Drews^{11

12}, Scott Haig³, Sheldon Cheskes¹³, David M Goldfarb⁹

Affiliations

¹ Centre for Health Evaluation & Outcome Sciences, University of British Columbia, Canada.
² Department of Emergency Medicine, University of British Columbia, Canada.
³ British Columbia Emergency Health Services, British Columbia, Canada.
⁴ Faculty of Medicine, Clinical Epidemiology, Memorial University of Newfoundland, Canada.
⁵ Department of Pediatrics, University of British Columbia, Canada.
⁶ School of Population and Public Health, University of British Columbia, Canada.
⁷ Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
⁸ Ontario Occupational Cancer Research Centre, Ontario, Canada.
⁹ Department of Pathology and Laboratory Medicine, University of British Columbia, Canada.
¹⁰ Public Health Laboratory, British Columbia Centre for Disease Control, British Columbia, Canada.
¹¹ Canadian, Blood Services Canada.
¹² Laboratory Medicine and Pathology, University of Alberta, Alberta, Canadaand.
¹³ Li Ka Shing Knowledge Institute and Division of Emergency Medicine, Department of Family and Community Medicine, University of Toronto, Ontario, Canada.

Abstract

The optimal dosing interval for severe acute respiratory syndrome coronavirus 2 vaccines remains controversial. In this prospective study, we compared serology results of paramedics vaccinated with mRNA vaccines at the recommended short (17-28 days) vs long (42-49 days) interval. We found that a long dosing interval resulted in higher spike, receptor binding domain, and spike N terminal domain antibody concentrations.

Keywords: COVID-19; SARS-CoV-2; antibodies; spike; vaccine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Viral
Antibody Formation
COVID-19 Vaccines
COVID-19* / prevention & control
Humans
Prospective Studies
SARS-CoV-2*
Spike Glycoprotein, Coronavirus

Substances

Antibodies, Viral
COVID-19 Vaccines
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2