The adjunctive effect of autologous platelet concentrates on orthodontic tooth movement: A systematic review and meta-analysis of current randomized controlled trials

Nima Farshidfar; Mohammad Amin Amiri; Parsa Firoozi; Shahram Hamedani; Shabnam Ajami; Lobat Tayebi

doi:10.1016/j.ortho.2021.10.004

The adjunctive effect of autologous platelet concentrates on orthodontic tooth movement: A systematic review and meta-analysis of current randomized controlled trials

Int Orthod. 2022 Mar;20(1):100596. doi: 10.1016/j.ortho.2021.10.004. Epub 2021 Dec 2.

Authors

Nima Farshidfar¹, Mohammad Amin Amiri², Parsa Firoozi³, Shahram Hamedani⁴, Shabnam Ajami⁵, Lobat Tayebi⁶

Affiliations

¹ Orthodontic Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: n.farshidfar@icloud.com.
² Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mamiri1378@yahoo.com.
³ Department of Oral and Maxillofacial Surgery, School of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran; Student Research Committee, School of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran. Electronic address: parsafir2@gmail.com.
⁴ Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: shahramhamedani@yahoo.com.
⁵ Orthodontic Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: dr.ajami.sh@gmail.com.
⁶ Marquette University School of Dentistry, Milwaukee, WI, USA. Electronic address: lobat.tayebi@marquette.edu.

Abstract

Objective: To evaluate the effectiveness of autologous platelet concentrates (APCs) as adjuncts on accelerating orthodontic tooth movement (OTM) of the human subjects undergoing orthodontic treatment and to critically appraise the available literature.

Methods and materials: Five electronic databases (PubMed, Scopus, Web of Science, Embase, and Cochrane Central Register of Controlled Trials) were searched from 2000 up to May 2021 to retrieve eligible randomized controlled trials (RCTs) investigating patients who underwent orthodontic treatment that involved OTM of maxillary and mandibular incisors and canines. All the enrolled cases were treated with APCs and had no local or systemic interfering factors. The quality of the included studies was assessed using the modified JADAD scale. The effect sizes were assessed using mean difference (MD). The heterogeneity analysis was conducted using (I²) statistic at α=0.10.

Results: Finally, seven RCTs were included in the qualitative, and two RCTs were included in the quantitative analysis. The meta-analysis was performed regarding the effect of injectable platelet-rich fibrin (I-PRF) on the rate of canine tooth movement in millimeters at different intervals of the 1^st, 2^nd, and 3^rd months. In the 1^st month, I-PRF (WMD:0.12mm, CI95% -5.01 to 5.24, I²=90%) did not significantly affect OTM. In the 2^nd month, I-PRF (WMD:0.66mm, CI95% 0.60 to 0.73, I²=10%) significantly increased the OTM. However, in the 3^rd month, I-PRF did not significantly increase the OTM (WMD:0.54mm, CI95% -1.38 to 2.47, I²=67%).

Conclusions: According to the low certainty of evidence about this topic, providing a definite conclusion is not possible. However, applying I-PRF seems to be efficient in accelerating the OTM of the canines. Further high-quality studies with larger sample sizes will be indispensable to validate this conclusion.

Keywords: PRF; PRP; Platelet-rich Fibrin; Platelet-rich Plasma; Tooth Movement Techniques.

Publication types

Meta-Analysis
Research Support, N.I.H., Extramural
Systematic Review

MeSH terms

Cuspid
Humans
Incisor
Platelet-Rich Fibrin*
Randomized Controlled Trials as Topic
Tooth Movement Techniques* / methods

Abstract

Publication types

MeSH terms

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