Gaps and Opportunities to Improve Prevention of Human Papillomavirus-Related Cancers

J Womens Health (Larchmt). 2021 Dec;30(12):1667-1672. doi: 10.1089/jwh.2021.0507. Epub 2021 Dec 6.

Abstract

Human papillomavirus (HPV) infections cause more than 35,900 cancers annually in the United States. Although cervical cancer is the most prevalent HPV-related malignancy in women, the virus is also responsible for a significant percentage of anal, vaginal, and vulvar cancers. A comprehensive approach to mitigating cervical cancer includes HPV vaccination (primary prevention), screening and treatment of precancerous lesions (secondary prevention), and diagnosis and treatment of invasive cancer (tertiary prevention). Although a successful strategy, there are opportunities to innovate and increase access that can also be adapted to address the unique clinical care gaps that exist with the other anogenital cancers. The Society for Women's Health Research held a series of interdisciplinary meetings and events, during which expert researchers, clinicians, patient advocates, and health care policy leaders evaluated the current landscape of HPV-related cancers and their effects on women's health. This report summarizes the discussions of this working group and areas it identified in which to address gaps in primary and secondary prevention approaches to improve access and health outcomes for women with HPV-related anogenital cancers.

Keywords: HPV vaccine; anal cancer; cancer screening; cervical cancer; stigma; vaginal cancer; vulvar cancer.

MeSH terms

  • Alphapapillomavirus*
  • Female
  • Humans
  • Papillomaviridae
  • Papillomavirus Infections* / diagnosis
  • Papillomavirus Infections* / prevention & control
  • Papillomavirus Vaccines*
  • United States / epidemiology
  • Uterine Cervical Neoplasms* / diagnosis
  • Uterine Cervical Neoplasms* / prevention & control
  • Vulvar Neoplasms* / diagnosis
  • Vulvar Neoplasms* / prevention & control

Substances

  • Papillomavirus Vaccines