Early testicular maturation is sensitive to depletion of spermatogonial pool in sickle cell disease

Klara M Benninghoven-Frey; Nina Neuhaus; Atte K Lahtinen; Claudia Krallmann; Joana M D Portela; Andrea Jarisch; Verena Nordhoff; Armin Soave; Hajar A M Ba Omar; Mikael Sundin; Cecilia Langenskiöld; Sabine Kliesch; Jan-Bernd Stukenborg; Kirsi Jahnukainen

doi:10.3324/haematol.2021.279253

Early testicular maturation is sensitive to depletion of spermatogonial pool in sickle cell disease

Haematologica. 2022 Apr 1;107(4):975-979. doi: 10.3324/haematol.2021.279253.

Affiliations

¹ Centre of Reproductive Medicine and Andrology, University of Münster and University Clinic Münster, Münster.
² Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Medical and Clinical Genetics / Medicum, Faculty of Medicine, University of Helsinki, Helsinki.
³ Center for Reproductive Medicine, Research Institute Reproduction and Development, Amsterdam Universitair Medische Centra, University of Amsterdam, Amsterdam.
⁴ Division of Stem Cell Transplantation and Immunology, Department of Children and Adolescent Medicine, University Hospital Frankfurt, Johann Wolfgang Goethe University, Frankfurt am Main.
⁵ Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg.
⁶ NORDFERTIL Research Lab Stockholm, Department of Women's and Children's Health, Karolinska Institutet, and Karolinska University Hospital, Stockholm.
⁷ Division of Paediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden; Section of Hematology, Immunology and HCT, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm.
⁸ Department of Pediatric Oncology, The Queen Silvia Children's Hospital, Gothenburg.
⁹ NORDFERTIL Research Lab Stockholm, Department of Women's and Children's Health, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden; New Children's Hospital, Paediatric Research Centre, University of Helsinki and Helsinki University Hospital, Helsinki. Kirsi.Jahnukainen@ki.se.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anemia, Sickle Cell* / genetics
Humans
Male
Spermatogonia*

Grants and funding

Funding:this study was supported by grants from The Swedish Childhood Cancer Foundation (PR2019-0123; TJ2020-0023; PR2015-0073, TJ2015-0046) (JBS, KJ), the Jane and Dan Olssons Foundation (2016-33) (JBS), the Finnish Cancer Society (KJ), the Finnish Foundation for Pediatric Research (KJ), the Magnus Bervalls Foundation (JBS), the Swedish Research Council (2018-03094; 2016-01296) (JBS, KJ), the Birgitta and Carl-Axel Rydbeck’s Research Grant for Pediatric Research (2020-00348; 2020-00335) (JBS, KJ), and the Väre Foundation for Pediatric Cancer Research (AKL, KJ). This work was also supported by the German Research Foundation Grand CRU326 (NN). Moreover, we thank the Faculty of Medicine of the University of Münster for the financial support of KMBF.