Autoantibodies and SARS-CoV2 infection: The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies

Jan Damoiseaux; Arad Dotan; Marvin J Fritzler; Dimitrios P Bogdanos; Pier Luigi Meroni; Dirk Roggenbuck; Michel Goldman; Nils Landegren; Paul Bastard; Yehuda Shoenfeld; Karsten Conrad

doi:10.1016/j.autrev.2021.103012

Autoantibodies and SARS-CoV2 infection: The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies

Autoimmun Rev. 2022 Mar;21(3):103012. doi: 10.1016/j.autrev.2021.103012. Epub 2021 Dec 9.

Authors

Affiliations

¹ Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address: jan.damoiseaux@mumc.nl.
² Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
³ Department of Medicine, Cumming School of Medicine, Calgary, Alberta, Canada.
⁴ Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
⁵ IRCCS Istituto Auxologico Italiano, Milan, Italy.
⁶ Faculty Environment and Natural Sciences and Faculty of Health Sciences Brandenburg, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany.
⁷ Institute for interdisciplinary innovation in healthcare, Université libre de Bruxelles, Belgium.
⁸ Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden; Department of Medicine (Solna), Centre for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
⁹ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France; Imagine Institute, University of Paris, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
¹⁰ Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Ariel University, Israel; Laboratory of the Mosaics of Autoimmunity, Saint Peterburg University, 199034, Russia.
¹¹ Institute of Immunology, Technical University of Dresden, Dresden, Germany.

Abstract

The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Symposium on Autoantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.

Keywords: Anti-IFNα; Antiphospholipid syndrome; Autoantibodies; Autoimmunity; COVID-19; MIS-C; Molecular mimicry; SARS-CoV-2.

Publication types

Review

MeSH terms

Autoantibodies
Autoimmunity
COVID-19*
Humans
RNA, Viral*
SARS-CoV-2

Substances

Autoantibodies
RNA, Viral