Self-renewal equality in pancreas homeostasis, regeneration, and cancer

Chiara Falcomatà; Dieter Saur

doi:10.1016/j.celrep.2021.110135

Self-renewal equality in pancreas homeostasis, regeneration, and cancer

Cell Rep. 2021 Dec 14;37(11):110135. doi: 10.1016/j.celrep.2021.110135.

Authors

Chiara Falcomatà¹, Dieter Saur²

Affiliations

¹ Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Chair of Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany. Electronic address: chiara.falcomata@tum.de.
² Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Chair of Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany. Electronic address: dieter.saur@tum.de.

PMID: 34910913
DOI: 10.1016/j.celrep.2021.110135

Abstract

Two studies by Lodestijn et al. in Cell Stem Cell and Cell Reports reveal a lack of stem cell hierarchies in acinar cell-derived tissue renewal and host instructed clonogenic growth of pancreatic cancer, thereby elucidating determinants of pancreas regeneration and cancer.

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MeSH terms

Acinar Cells
Homeostasis
Humans
Pancreas*
Pancreatic Neoplasms*
Stem Cells