Aseptic meningitis after BNT-162b2 COVID-19 vaccination

Amanda Cy Chan; Benjamin Yq Tan; Yihui Goh; Shaun Sy Tan; Paul A Tambyah

doi:10.1016/j.bbih.2021.100406

Aseptic meningitis after BNT-162b2 COVID-19 vaccination

Brain Behav Immun Health. 2022 Feb:19:100406. doi: 10.1016/j.bbih.2021.100406. Epub 2021 Dec 13.

Authors

Amanda Cy Chan^{1

2}, Benjamin Yq Tan^{1

2}, Yihui Goh¹, Shaun Sy Tan³, Paul A Tambyah^{2

4}

Affiliations

¹ Division of Neurology, Department of Medicine, National University Health System, Singapore.
² Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
³ Department of Laboratory Medicine, National University Hospital, Singapore.
⁴ Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore.

Abstract

The COVID-19 pandemic has had an unprecedented impact on healthcare systems globally, giving rise to significant morbidity and mortality. Vaccination has been widely regarded as the most important strategy to contain the pandemic. Whilst local side-effects of the BNT-162b2 (Pfizer-BioNTech) vaccine are well known, concern has emerged due to sporadic reports of immune-mediated adverse effects (Cines and Bussel, 2021; Rela et al., 2021). As of August 19, 2021, 4.54 million individuals had received COVID-19 vaccines in Singapore (Oxford Martin School UoO, 2021). We report a case series of two patients who developed aseptic meningitis after vaccination.

Keywords: Aseptic meningitis; BNT162b2; COVID-19; Vaccination; Vaccine; mrna.