Clone competition as a mechanism to reduce tumor formation

Amelia Acha-Sagredo; Ilaria Malanchi; Francesca D Ciccarelli

doi:10.1016/j.devcel.2021.12.003

Clone competition as a mechanism to reduce tumor formation

Dev Cell. 2021 Dec 20;56(24):3307-3308. doi: 10.1016/j.devcel.2021.12.003.

Authors

Amelia Acha-Sagredo¹, Ilaria Malanchi², Francesca D Ciccarelli³

Affiliations

¹ Cancer Systems Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
² Tumor Host Interaction Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
³ Cancer Systems Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK. Electronic address: francesca.ciccarelli@crick.ac.uk.

PMID: 34932947
DOI: 10.1016/j.devcel.2021.12.003

Abstract

With age, clones carrying somatic mutations in well-known cancer driver genes progressively populate adult tissues, yet cancer transformation is rare. In a recent issue of Nature, Colom et al. showed that competition between mutated clones with different fitness could act as a tumor-protective mechanism.

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MeSH terms

Adult
Cell Transformation, Neoplastic / genetics
Clone Cells
Humans
Mutation / genetics
Neoplasms* / genetics
Oncogenes