Caffeine increases performance and leads to a cardioprotective effect during intense exercise in cyclists

Sci Rep. 2021 Dec 21;11(1):24327. doi: 10.1038/s41598-021-03158-2.

Abstract

The present study was designed to investigate the effects of different caffeine dietary strategies to compare the impact on athletic performance and cardiac autonomic response. The order of the supplementation was randomly assigned: placebo(4-day)-placebo(acute)/PP, placebo(4-day)-caffeine(acute)/PC and caffeine(4-day)-caffeine(acute)/CC. Fourteen male recreationally-trained cyclists ingested capsules containing either placebo or caffeine (6 mg kg-1) for 4 days. On day 5 (acute), capsules containing placebo or caffeine (6 mg kg-1) were ingested 60 min before completing a 16 km time-trial (simulated cycling). CC and PC showed improvements in time (CC vs PP, Δ - 39.3 s and PC vs PP, Δ - 43.4 s; P = 0.00; ƞ2 = 0.33) and in output power (CC vs PP, Δ 5.55 w and PC vs PP, Δ 6.17 w; P = 0.00; ƞ2 = 0.30). At the final of the time-trial, CC and PC exhibited greater parasympathetic modulation (vagal tone) when compared to the PP condition (P < 0.00; ƞ2 = 0.92). Our study provided evidence that acute caffeine intake (6 mg∙kg-1) increased performance (time-trial) and demonstrated a relevant cardioprotective effect, through increased vagal tone.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Athletic Performance / physiology*
  • Bicycling / statistics & numerical data*
  • Caffeine / blood
  • Caffeine / pharmacology*
  • Cardiotonic Agents / blood
  • Cardiotonic Agents / pharmacology*
  • Central Nervous System Stimulants / blood
  • Central Nervous System Stimulants / pharmacology
  • Cross-Over Studies
  • Double-Blind Method
  • Exercise*
  • Heart Rate*
  • Humans
  • Male
  • Oxygen Consumption

Substances

  • Cardiotonic Agents
  • Central Nervous System Stimulants
  • Caffeine