HIV Drug Resistance in Kenyan Infants Diagnosed With HIV and Their Mothers

Pediatr Infect Dis J. 2022 Apr 1;41(4):312-314. doi: 10.1097/INF.0000000000003436.

Abstract

The presence and type of HIV drug resistance mutations among 5 infants diagnosed with HIV were assessed and compared with their mothers' viral mutations. Mother and infant blood samples were sequenced and screened for HIV drug resistance mutations using the Stanford HIV Sequence Database. Three of 5 (60%) mother-infant pairs harbored HIV drug resistance mutations.

MeSH terms

  • Anti-HIV Agents* / pharmacology
  • Anti-HIV Agents* / therapeutic use
  • Drug Resistance, Viral / genetics
  • Female
  • HIV Infections* / drug therapy
  • HIV-1* / genetics
  • Humans
  • Infant
  • Infectious Disease Transmission, Vertical
  • Kenya / epidemiology
  • Mothers

Substances

  • Anti-HIV Agents