Integrative approaches in genome structure analysis

Lorenzo Boninsegna; Asli Yildirim; Yuxiang Zhan; Frank Alber

doi:10.1016/j.str.2021.12.003

Integrative approaches in genome structure analysis

Structure. 2022 Jan 6;30(1):24-36. doi: 10.1016/j.str.2021.12.003. Epub 2021 Dec 27.

Authors

Lorenzo Boninsegna¹, Asli Yildirim¹, Yuxiang Zhan², Frank Alber³

Affiliations

¹ Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.
² Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.
³ Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: falber@g.ucla.edu.

Abstract

New technological advances in integrated imaging, sequencing-based assays, and computational analysis have revolutionized our view of genomes in terms of their structure and dynamics in space and time. These advances promise a deeper understanding of genome functions and mechanistic insights into how the nucleus is spatially organized and functions. These wide arrays of complementary data provide an opportunity to produce quantitative integrative models of nuclear organization. In this article, we highlight recent key developments and discuss the outlook for these fields.

Keywords: genome function; genome structure modeling; genomics experiments; nuclear architecture; super-resolution imaging.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Cell Nucleus / chemistry
Cell Nucleus / genetics*
Chromosomes, Human / chemistry*
Genome, Human
Humans
Models, Molecular
Molecular Conformation

Abstract

Publication types

MeSH terms

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