Symmetry Reduction in a Hyperpolarization-Activated Homotetrameric Ion Channel

Biochemistry. 2022 Oct 18;61(20):2177-2181. doi: 10.1021/acs.biochem.1c00654. Epub 2021 Dec 29.

Abstract

Plants obtain nutrients from the soil via transmembrane transporters and channels in their root hairs, from which ions radially transport in toward the xylem for distribution across the plant body. We determined structures of the hyperpolarization-activated channel AKT1 from Arabidopsis thaliana, which mediates K+ uptake from the soil into plant roots. These structures of AtAKT1 embedded in lipid nanodiscs show that the channel undergoes a reduction of C4 to C2 symmetry, possibly to regulate its electrical activation.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

MeSH terms

  • Arabidopsis Proteins* / metabolism
  • Arabidopsis* / metabolism
  • Gene Expression Regulation, Plant
  • Ion Channels
  • Lipids
  • Potassium / metabolism
  • Potassium Channels / genetics
  • Soil

Substances

  • Arabidopsis Proteins
  • Ion Channels
  • Lipids
  • Potassium Channels
  • Soil
  • Potassium